Penelitian (Uji) : Lepidium & Menopause
>> Minggu, 09 Agustus 2009
Basic Clinical
Pharmacology & Toxicology
Volume 97, Supplement I, 2005
Published by the Nordic Pharmacological Society
ABSTRACT BOOK
Proceedings of the 7th Congress of the European Association
for Clinical Pharmacology and Therapeutics
June 25-29, 2005, Poznan, Poland
PRE-GELATINISED MACA (LEPIDIUM PERUVIANUM CHACON) AS NON-HORMONAL HERBAL REMEDY TO TREAT MENOPAUSAL SYMPTOMS IN PRE- AND POSTMENOPAUSAL WOMEN
Meissner H.1, Reich-Bilinska H.2, Kedzia B.3, Mscisz A.3
1TTD International – Australia & CSU, Sydney, Australia,
2Private Gineacological Clinic, Glogow, Poland, 3Research Institute of Medicinal Plants, Poznan´ , Poland
Maca root (Lepidium peruvianum Chacon) is traditionally-used by natives of Peru as an energizing vegetable for men and women and as herbal remedy for menopausal symptoms.
Recently, it is increasingly used in the USA and Europe to treat conditions affecting
postmenopausal women. Laboratory studies indicate that Maca may also be of value in treating depressive symptoms in perimenopause.
In this three months, double blind study the effects of pregelatinized Maca-GO on 24 pre- and 25 post-menopausal women (aged 41–50 years and 48–62 years respectively) were examined. Level of sex hormones, Cortisol and Acetylcholine (ACTH) were measured as well as lipid profile and indices of menopausal discomfort were determined using menopausal index according to Greene and Kupperman. Post menopausal state was established on
the basis of Estrogen (E2) and Follicle Stimulating Hormone (FSH) levels (below 40 pg/ml and above 30 IU/ml respectively). Two 500 mg capsules with Maca-GO powder were self-administered twice daily with meals (total 2 g/day) for the period of two months preceded by one month placebo period. Toxicity of Maca determined on rats showed its safe use at the level of 7.5 mg/kg body weight.
Two months administration of Maca-GO significantly alleviated symptoms of discomfort observed in both groups of women as assessed by menopausal index. This was associated with significant increase in E2 and reduction in FSH, Triglycerides and Cholesterol blood levels. A significant increase in both Progesterone and ACTH levels was observed in pre-menopausal women with significant ACTH reduction in post-menopausal group.
The results showed that pre-gelatinized Maca-GO may be a valuable non-hormonal
plant preparation for balancing levels of hormones and alleviating negative physiological and psychological symptoms (depression and stress) experienced by women not only in post-menopause, but even more so in those, entering early and advanced perimenopausal
stage.
Kesimpulan : Lepidium Peruvianum adalah tanaman non hormonal yang santa bernilai untuk membantu menyeimbangkan kadar hormon dan mengurangi efek negatif dari gejala psikis dan fisiologis (depresi & strees) yang dialami wanita post menopause
Pharmacology & Toxicology
Volume 97, Supplement I, 2005
Published by the Nordic Pharmacological Society
ABSTRACT BOOK
Proceedings of the 7th Congress of the European Association
for Clinical Pharmacology and Therapeutics
June 25-29, 2005, Poznan, Poland
PRE-GELATINISED MACA (LEPIDIUM PERUVIANUM CHACON) AS NON-HORMONAL HERBAL REMEDY TO TREAT MENOPAUSAL SYMPTOMS IN PRE- AND POSTMENOPAUSAL WOMEN
Meissner H.1, Reich-Bilinska H.2, Kedzia B.3, Mscisz A.3
1TTD International – Australia & CSU, Sydney, Australia,
2Private Gineacological Clinic, Glogow, Poland, 3Research Institute of Medicinal Plants, Poznan´ , Poland
Maca root (Lepidium peruvianum Chacon) is traditionally-used by natives of Peru as an energizing vegetable for men and women and as herbal remedy for menopausal symptoms.
Recently, it is increasingly used in the USA and Europe to treat conditions affecting
postmenopausal women. Laboratory studies indicate that Maca may also be of value in treating depressive symptoms in perimenopause.
In this three months, double blind study the effects of pregelatinized Maca-GO on 24 pre- and 25 post-menopausal women (aged 41–50 years and 48–62 years respectively) were examined. Level of sex hormones, Cortisol and Acetylcholine (ACTH) were measured as well as lipid profile and indices of menopausal discomfort were determined using menopausal index according to Greene and Kupperman. Post menopausal state was established on
the basis of Estrogen (E2) and Follicle Stimulating Hormone (FSH) levels (below 40 pg/ml and above 30 IU/ml respectively). Two 500 mg capsules with Maca-GO powder were self-administered twice daily with meals (total 2 g/day) for the period of two months preceded by one month placebo period. Toxicity of Maca determined on rats showed its safe use at the level of 7.5 mg/kg body weight.
Two months administration of Maca-GO significantly alleviated symptoms of discomfort observed in both groups of women as assessed by menopausal index. This was associated with significant increase in E2 and reduction in FSH, Triglycerides and Cholesterol blood levels. A significant increase in both Progesterone and ACTH levels was observed in pre-menopausal women with significant ACTH reduction in post-menopausal group.
The results showed that pre-gelatinized Maca-GO may be a valuable non-hormonal
plant preparation for balancing levels of hormones and alleviating negative physiological and psychological symptoms (depression and stress) experienced by women not only in post-menopause, but even more so in those, entering early and advanced perimenopausal
stage.
Kesimpulan : Lepidium Peruvianum adalah tanaman non hormonal yang santa bernilai untuk membantu menyeimbangkan kadar hormon dan mengurangi efek negatif dari gejala psikis dan fisiologis (depresi & strees) yang dialami wanita post menopause
0 komentar:
Posting Komentar