Penelitian (Uji) : Lepidium & Menopause
>> Minggu, 09 Agustus 2009
Basic Clinical
Pharmacology & Toxicology
Volume 97, Supplement I, 2005
Published by the Nordic Pharmacological Society
ABSTRACT BOOK
Proceedings of the 7th Congress of the European Association
for Clinical Pharmacology and Therapeutics
June 25-29, 2005, Poznan, Poland
SHORT- AND LONG-TERM PHYSIOLOGICAL RESPONSES OF MALE AND FEMALE RATS TO TWO DIETARY LEVELS OF PRE-GELATINISED MACA
(LEPIDIUM PERUVIANUM CHACON)
Meissner H.1, Kedzia B.2, Mrozikiewicz PM.2, Mscisz A.2
1TTD International – Australia & CSU, Sydney, Australia,
2Research Institute of Medicinal Plants, Poznan, Poland
Roots of Maca (Lepidium peruvianum Chacon) are used by natives of Peru as an energizing vegetable with invigorating, restorative and rejuvenating properties, reducing stress effect, increasing fertility and enhancing libido in both men and women.
Current international interest in Maca is due to its energizing and revitalizing properties
and its successful use in treating pre- and post-menopausal symptoms. In this study, the effect of pre-gelatinized (extruded)
Maca-GO powder was investigated on Sprague-Dowley male (45) and female (45) rats receiving two dietary levels of powder (0.75 g/ kg and 7.5 g/kg body weight) and assessed against control during 28 and 90 days trials. Blood morphology, levels of sex hormones, lipid profile, and histology of internal organs were determined and muscles and bones of rats were analyzed. As compared to the control group, after 28 days of trial, at both levels of Maca-GO intake,
weight of males reduced significantly without effect on females, with significant increase in red cell volume, lymphocyte count in both sexes and significant decrease in triglycerides and Cortisol level.
Low level of Maca-GO intake by female rats had no effect on Progesterone
and Estrogen but high intake resulted in nearly four times increase in the Estrogen level as compared to control group. After 90 day intake, Maca-GO significantly increased blood glucose, bone calcium and phosphorus levels, decreased blood potassium and cortisol levels in both sexes and tissue lipids in males only with significant increase in Progesterone and tissue lipids in female rats. Nodifferences were recorded between test and corresponding control rats in blood morphology and histopathology of internal organs.
Obtained results showed that pre-gelatinized Maca-GO is safe for short-term and extended use as dietary supplement or in functional preparations. Different responses observed in male and female rats to both different levels of Maca-GO intake and the length of its administration warrant further more detail study.
Kesimpulan : Lepdium Peruvianum adalah tanaman yang sangat aman untuk membantu mengatasi masalah menopause
Pharmacology & Toxicology
Volume 97, Supplement I, 2005
Published by the Nordic Pharmacological Society
ABSTRACT BOOK
Proceedings of the 7th Congress of the European Association
for Clinical Pharmacology and Therapeutics
June 25-29, 2005, Poznan, Poland
SHORT- AND LONG-TERM PHYSIOLOGICAL RESPONSES OF MALE AND FEMALE RATS TO TWO DIETARY LEVELS OF PRE-GELATINISED MACA
(LEPIDIUM PERUVIANUM CHACON)
Meissner H.1, Kedzia B.2, Mrozikiewicz PM.2, Mscisz A.2
1TTD International – Australia & CSU, Sydney, Australia,
2Research Institute of Medicinal Plants, Poznan, Poland
Roots of Maca (Lepidium peruvianum Chacon) are used by natives of Peru as an energizing vegetable with invigorating, restorative and rejuvenating properties, reducing stress effect, increasing fertility and enhancing libido in both men and women.
Current international interest in Maca is due to its energizing and revitalizing properties
and its successful use in treating pre- and post-menopausal symptoms. In this study, the effect of pre-gelatinized (extruded)
Maca-GO powder was investigated on Sprague-Dowley male (45) and female (45) rats receiving two dietary levels of powder (0.75 g/ kg and 7.5 g/kg body weight) and assessed against control during 28 and 90 days trials. Blood morphology, levels of sex hormones, lipid profile, and histology of internal organs were determined and muscles and bones of rats were analyzed. As compared to the control group, after 28 days of trial, at both levels of Maca-GO intake,
weight of males reduced significantly without effect on females, with significant increase in red cell volume, lymphocyte count in both sexes and significant decrease in triglycerides and Cortisol level.
Low level of Maca-GO intake by female rats had no effect on Progesterone
and Estrogen but high intake resulted in nearly four times increase in the Estrogen level as compared to control group. After 90 day intake, Maca-GO significantly increased blood glucose, bone calcium and phosphorus levels, decreased blood potassium and cortisol levels in both sexes and tissue lipids in males only with significant increase in Progesterone and tissue lipids in female rats. Nodifferences were recorded between test and corresponding control rats in blood morphology and histopathology of internal organs.
Obtained results showed that pre-gelatinized Maca-GO is safe for short-term and extended use as dietary supplement or in functional preparations. Different responses observed in male and female rats to both different levels of Maca-GO intake and the length of its administration warrant further more detail study.
Kesimpulan : Lepdium Peruvianum adalah tanaman yang sangat aman untuk membantu mengatasi masalah menopause
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