Penelitian (Uji) : Lepidium sebagai terapi non hormonal
>> Minggu, 09 Agustus 2009
Menopause, The Journal Of The North American Society, Vol 16, Number 5, 2005
Femenessence Macapause Abstract
Hormone-balancing and Pharmacological Effects of Therapeutic Doses of Lepidium peruvianum (Maca-GO) in postmenopausal women
H.O. Meissner, PhD1, H. Reich-Bilinska, MD2, P. Mrozikiewicz, DSc3, A.
Mscisz, PhD3, A. Lowicka, MSc3, Bobkiewicz-Kozlowska, Prof. Dr4, B.
Kedzia PhD3,
1 Department of Health Studies Charles Sturt University &
Therapeutic Research Services, TTD International, Sydney, Australia,
2Private Gyn. Clinic, Glogow, Poland,
3Research Institute of Medicinal Plants, Poznan,
Poland,
4Department of Pharmacology, Medical University, Poznan, Poland.
Objective: To examine hormone-balancing effects of therapeutic doses of gelatinized organic preparation of Lepidium peruvianum Chacon (Maca-GO) in model pharmacological laboratory Trials and on early postmenopausal women in a multi-centre clinical study.
Design: Participants for this 3-month (one month placebo and 2 month treatment), double-blind, randomized, placebo-corrected, study were women who were in good health, ceased menstruation (>6 and <18>30 IU/ml levels in a blood at the baseline, total 100 women volunteers were enrolled. They self-administered two hard
gel capsules twice daily, each containing 500mg Maca-GO or identicalappearing placebo capsules containing inert ingredients.
At baseline and follow-up monthly intervals, the following measurements were recorded by
gynecologists in four clinics: level of sex hormones: E2, FSH, LH and Progesterone (PG), index of menopausal symptoms according to Kupperman (KMI). Additionally, in a 28-day parallel study on ovariectomised (by laparotomy) Wistar rats, the effect of 2 x 250mg/kg body weight (b.w.) Maca- GO daily on antidepressive function (Porsolt’s test), anxiolytic sedative and cognitive effects (using elevated-plus maze, locomotor activity and passive avoidance tests) were assessed against control (laparotomised rats only). Prior to the study, toxicity of used Maca-GO was determined analytically and in bioassay on mice and rats.
Results: Analytically-determined non-toxic status of Maca-GO was confirmed in bioassays when applied to mice and rats at levels of 7.5 and up to 15g/kg b.w. Two months administration of Maca-GO significantly increased (P<0.05) E2 and reduced (P<0.05) FSH levels in 89 women who concluded the study and alleviated (P<0.05) symptoms of menopausal discomfort as assessed by the KMI (from 43 to 17). Maca-GO showed a distinctive, (P<0.05) antidepressant-like and sedative effect in ovariectomised rats only, while there was no anxiolytic activity nor disturbance of cognitive function observed in both, test and control animals.
Conclusion: Observed in this study balancing effect of Maca-GO on sex hormone levels and reduction in KMI score, show its value as a non-hormonal plant alternative to HRT program, relieving most of the symptoms experienced by women not only in early post-menopause, but potentially even more so at the pre-menopausal stage.
Kesimpulan : Lepidium peruvianum sangat baik digunakan sebagai terapi non hormonal untuk mengatasi gejala yang dialami wanita menopause .
Femenessence Macapause Abstract
Hormone-balancing and Pharmacological Effects of Therapeutic Doses of Lepidium peruvianum (Maca-GO) in postmenopausal women
H.O. Meissner, PhD1, H. Reich-Bilinska, MD2, P. Mrozikiewicz, DSc3, A.
Mscisz, PhD3, A. Lowicka, MSc3, Bobkiewicz-Kozlowska, Prof. Dr4, B.
Kedzia PhD3,
1 Department of Health Studies Charles Sturt University &
Therapeutic Research Services, TTD International, Sydney, Australia,
2Private Gyn. Clinic, Glogow, Poland,
3Research Institute of Medicinal Plants, Poznan,
Poland,
4Department of Pharmacology, Medical University, Poznan, Poland.
Objective: To examine hormone-balancing effects of therapeutic doses of gelatinized organic preparation of Lepidium peruvianum Chacon (Maca-GO) in model pharmacological laboratory Trials and on early postmenopausal women in a multi-centre clinical study.
Design: Participants for this 3-month (one month placebo and 2 month treatment), double-blind, randomized, placebo-corrected, study were women who were in good health, ceased menstruation (>6 and <18>30 IU/ml levels in a blood at the baseline, total 100 women volunteers were enrolled. They self-administered two hard
gel capsules twice daily, each containing 500mg Maca-GO or identicalappearing placebo capsules containing inert ingredients.
At baseline and follow-up monthly intervals, the following measurements were recorded by
gynecologists in four clinics: level of sex hormones: E2, FSH, LH and Progesterone (PG), index of menopausal symptoms according to Kupperman (KMI). Additionally, in a 28-day parallel study on ovariectomised (by laparotomy) Wistar rats, the effect of 2 x 250mg/kg body weight (b.w.) Maca- GO daily on antidepressive function (Porsolt’s test), anxiolytic sedative and cognitive effects (using elevated-plus maze, locomotor activity and passive avoidance tests) were assessed against control (laparotomised rats only). Prior to the study, toxicity of used Maca-GO was determined analytically and in bioassay on mice and rats.
Results: Analytically-determined non-toxic status of Maca-GO was confirmed in bioassays when applied to mice and rats at levels of 7.5 and up to 15g/kg b.w. Two months administration of Maca-GO significantly increased (P<0.05) E2 and reduced (P<0.05) FSH levels in 89 women who concluded the study and alleviated (P<0.05) symptoms of menopausal discomfort as assessed by the KMI (from 43 to 17). Maca-GO showed a distinctive, (P<0.05) antidepressant-like and sedative effect in ovariectomised rats only, while there was no anxiolytic activity nor disturbance of cognitive function observed in both, test and control animals.
Conclusion: Observed in this study balancing effect of Maca-GO on sex hormone levels and reduction in KMI score, show its value as a non-hormonal plant alternative to HRT program, relieving most of the symptoms experienced by women not only in early post-menopause, but potentially even more so at the pre-menopausal stage.
Kesimpulan : Lepidium peruvianum sangat baik digunakan sebagai terapi non hormonal untuk mengatasi gejala yang dialami wanita menopause .
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